Current Generative AI systems, especially Transformer based Large Language Models (LLM) surprised even the founders of Deep Neural Network based AI research. Trained on vast amounts of human, and computer, language they have learned not only how to understand and communicate using these languages, but also some human reasoning, and even aspects of human nature; making them very different from the programmed computer systems we are used to. eSpeakeasy is a collection of thoughts on how we can effectively collaborate with AI agents to be more productive and effective in many aspects of our work and other aspects of our lives.